NMN: dosage in studies
Not a recommendation, not treatment guidance. This page shows only what published human studies used, with sources. This site does not say how much anyone should use of any substance. The content and quality of a product bought online or as a supplement are not controlled like a medicine's.
In the studies in the table, NMN was taken by mouth at 250-1,250 mg a day for four to 12 weeks [1, 2, 3, 4]A.
In the meta-analyses, the included trials used 250-2,000 mg a day [5, 7]A.
Doses used in studies
| Study | Participants | Dose | Frequency | Duration | Source and level |
|---|---|---|---|---|---|
| Yoshino 2021 | 25 postmenopausal women with overweight and prediabetes (13 received NMN) | 250 mg a day by mouth | Daily | 10 weeks | [1]A |
| Igarashi 2022 | 42 men aged 65 or over (21 received NMN) | 250 mg a day by mouth | Daily | 6 or 12 weeks | [2]A |
| Yi 2023, 300 mg | 80 healthy middle-aged adults (placebo or 300, 600 or 900 mg) | 300 mg by mouth | Once a day | 60 days | [3]A |
| Yi 2023, 600 mg | 80 healthy middle-aged adults (placebo or 300, 600 or 900 mg) | 600 mg by mouth | Once a day | 60 days | [3]A |
| Yi 2023, 900 mg | 80 healthy middle-aged adults (placebo or 300, 600 or 900 mg) | 900 mg by mouth | Once a day | 60 days | [3]A |
| Fukamizu 2022 | 31 healthy adults aged 20-65 (16 received NMN) | 1,250 mg by mouth | Once a day | Up to 4 weeks | [4]A |
Evidence levels: A = randomised human trial or meta-analysis · B = observational human study or case series · C = animal study · D = cell or laboratory study · E = not peer-reviewed
Notes
The trials were small, with 25-80 participants, and short [1, 2, 3, 4]A.
In two trials the company supplying the NMN was involved: Fukamizu 2022 was funded and supplied by Mitsubishi Corporation Life Sciences, and three authors of Igarashi 2022 were employees of the same company [2, 4]A.
What points the other way or is uncertain
In a meta-analysis of eight randomised trials, 250-2,000 mg a day for 14 days to 12 weeks did not improve fasting glucose, insulin, HbA1c or blood lipids [5]A.
According to a meta-analysis in people over 60, NMN did not affect muscle mass, grip strength or walking speed [6]A.
A 2026 meta-analysis found no broad metabolic benefit for weight, blood glucose or lipids; only diastolic blood pressure fell slightly [7]A.
Read the research yourself: sources
- Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. PMID 33888596
- Igarashi M, Nakagawa-Nagahama Y, Miura M, et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging. 2022;8(1):5. PMID 35927255
- Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023;45(1):29-43. PMID 36482258
- Fukamizu Y, Uchida Y, Shigekawa A, et al. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Sci Rep. 2022;12(1):14442. PMID 36002548
- Chen F, Zhou D, Kong AP, et al. Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials. Curr Diab Rep. 2024;25(1):4. PMID 39531138
- Prokopidis K, Moriarty F, Bahat G, et al. The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis. J Cachexia Sarcopenia Muscle. 2025;16(3):e13799. PMID 40275690
- Yang W, Huang J, Tang Z, et al. Safety and Metabolism-Related Outcomes of Oral Nicotinamide Mononucleotide Supplementation in Adults: A Systematic Review and Meta-Analysis. Nutrients. 2026;18(14):2251. PMID 42514320
Sources checked in PubMed on 12 Oct 2026. The amount in Yoshino 2021 (250 mg a day) and participant numbers for [1,2,4] are from the full text of the studies.
Content is general information about research, not medical advice. If you have symptoms, contact a healthcare professional.